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Table 2 A summary of the HER2 fusion status

From: Oncogenic HER2 fusions in gastric cancer

Sample ID Fusion Type(RNA) DNA structure 5' fusion partner status HER2 status
GC196 ZNF207_exon2 /HER2_exon18 ZNF207_intron2/HER2_intron17 ZNF207 mRNA expression High mRNA Expression High
Gene copy N Ter AMP Gene Copy C Ter AMP
Protein level - Protein level IHC 3+
431-9540474 T MDK_exon4 -/HER2_exon11 MDK_intron4/HER2_intron10 MDK mRNA expression High mRNA Expression High
Gene copy tAMP Gene Copy tAMP
Protein level - Protein level -
GC334 NOS2_exon2 /HER2_exon2 NOS2_intron2/HER2_5’UTR NOS2 mRNA expression Low mRNA Expression High
Gene copy N Ter AMP Gene Copy tAMP
Protein level - Protein level IHC 3+
  1. N Ter AMP: N terminal amplification.
  2. C Ter AMP: C terminal amplification.
  3. tAMP: total amplification.