Skip to main content

Table 2 A summary of the HER2 fusion status

From: Oncogenic HER2 fusions in gastric cancer

Sample ID

Fusion Type(RNA)

DNA structure

5' fusion partner status

HER2 status

GC196

ZNF207_exon2 /HER2_exon18

ZNF207_intron2/HER2_intron17

ZNF207

mRNA expression

High

mRNA Expression

High

Gene copy

N Ter AMP

Gene Copy

C Ter AMP

Protein level

-

Protein level

IHC 3+

431-9540474 T

MDK_exon4 -/HER2_exon11

MDK_intron4/HER2_intron10

MDK

mRNA expression

High

mRNA Expression

High

Gene copy

tAMP

Gene Copy

tAMP

Protein level

-

Protein level

-

GC334

NOS2_exon2 /HER2_exon2

NOS2_intron2/HER2_5’UTR

NOS2

mRNA expression

Low

mRNA Expression

High

Gene copy

N Ter AMP

Gene Copy

tAMP

Protein level

-

Protein level

IHC 3+

  1. N Ter AMP: N terminal amplification.
  2. C Ter AMP: C terminal amplification.
  3. tAMP: total amplification.