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Table 2 Clinical and pathological characteristics of established xenograft models

From: Establishment of patient-derived xenograft models and cell lines for malignancies of the upper gastrointestinal tract

ID Gender Age Location Stage (TNM) Diagnosis Diff. patient Diff. xeno Xeno take* Cell lines Treatment +
PC028 F 74 liver metastasis pTxNxM1 PDAC moderate moderate 4 yes none
PC053M M 78 liver metastasis pTxN1M1 PDAC moderate poor 12 yes none
PC053B M 78 biopsy tumor pTxN1M1 PDAC na poor 12 yes none
PC067 F 73 resected tumor pT3N1M0 PDAC poor moderate 26 yes none
PC072 M 65 resected tumor pT3N1M0 PDAC moderate moderate 24 no growth none
PC076 M 64 resected tumor pT3N1M0 PDAC poor-moderate moderate 33 yes none
PC084 M 83 liver metastasis pTxN1M1 PDAC moderate-well moderate 11 yes none
PC086 M 66 resected tumor pT4N1M0 PDAC moderate moderate 18 na none
PC090 F 78 resected tumor pT4N1M0 PDAC moderate well 19 yes none
PC093 M 61 resected tumor pT4N1M0 PDAC moderate moderate 37 ongoing none
PC096 F 62 liver metastasis pTxNxM1 PDAC moderate moderate 29 ongoing none
PC099 F 46 liver metastasis cT3NxM1 PDAC well moderate 23 ongoing none
EAC007B F 50 biopsy tumor pT3N1M0 EAC moderate moderate-well 10 yes none
EAC007R F 51 resected tumor pT3N1M0 EAC moderate poor-moderate 19 yes chemoradiation
ESC008 F 37 resected tumor pT4N0M0 ESC moderate poor-moderate 3 na chemoradiation
EAC018 M 73 resected tumor pT3N1M0 EAC moderate moderate-well 16 yes chemoradiation
EAC023 M 58 biopsy tumor pT3N2M0 EAC poor poor 14 yes none
EAC026 M 69 lymph node metastasis pT2N2M0 EAC poor poor 16 yes chemoradiation
EAC027 M 66 adrenal gland metastasis pT3NxM1 EAC poor poor 14 yes radiation
EAC031B M 78 biopsy tumor pT3N3Mx EAC moderate poor 14 yes none
EAC031M M 78 liver metastasis pT3N3Mx EAC moderate moderate 17 yes chemotherapy
EAC033 M 54 liver metastasis pT4N2M1 EAC poor poor 16 yes chemotherapy
EAC037 M 68 thoracle TH metastasis na EAC poor poor 11 yes chemotherapy
EAC038 M 76 lung metastasis pT3N1M0 EAC poor poor 28 na chemoradiation
ESC040 F 67 pelvis metastasis pTxN2Mx ESC moderate poor-moderate 17 ongoing chemoradiation
EAC041 M 73 biopsy tumor pTxN1M0 EAC moderate moderate 3 ongoing none
ESC043 M 58 biopsy tumor pT3N1Mx ESC na moderate-well 10 na none
ESC049 F 66 biopsy tumor pT3N1M0 ESC moderate moderate 12 na none
EAC050 M 69 biopsy tumor pT3N2Mx EAC na poor-moderate 11 na none
  1. *time in weeks required for the primary patient material to grow out and be retransplanted.
  2. +neo-adjuvant treatment before resection.
  3. Abbrevations: M male, F female, Diff. Differentiation grade, na not assessed due to limited or inconclusive material, PDAC pancreatic ductal adenocarcinoma, EAC esophageal adenocarcinoma, ESC esophageal squamous cell carcinoma.