Figure 1

Validated signaling pathways that modulate H19 lncRNA expression. Shown are different signaling pathways reported recently that modulate the H19 lncRNA expression. Inside the circle are upstream transcription factors and signal transducers that modulate H19 lncRNA expression. Outside the circle are the downstream targets of either H19/miR-675. These signaling pathways play different fundamental roles in tumor biology including lung tumorigenesis.