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Table 1 Clinical characteristics and laboratory variables of patients subjected to ELISA analysis

From: Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

  Healthy volunteers Renal diseases other than ADPKD ADPKD
Total Early Advanced
Cases (n) 17 50 66 36 30
Age (Years)* 34.9 ± 11.1 65.3 ± 12.6 43.1 ± 17.2 31.9 ± 12.7 56.3 ± 11.5
Gender (n)**
• Male 53 (9) 66 (33) 48 (32) 50 (18) 47 (14)
• Female 47 (8) 34 (17) 52 (34) 50 (18) 53 (16)
Pathologies (n)**
• Diabetes - 20 (10) 3 (2) - 6 (2)
• Obesity (BMI > 30 kg/m2) - 16 (8) 3 (2) 3 (1) 3 (1)
• Hypercholesterolemia - 24 (12) 7 (5) - 16 (5)
eGFR [mL/min/1.73 m2]* N.A. 30.0 ± 15.1 71.8 ± 38.8 102.5 ± 20.6 35.4 ± 17.4
Proteinuria [g/ mmol creatinine]* N.A. 0.621 ± 0.06 0.139 ± 0.05 0.101 ± 0.04 0.215 ± 0.02
High BP, (n)** - 44 (22) 85 (56) 75 (27) 96 (29)
Fetuin-A (U) [μg/L]* 78.7 ± 39.5 39.2 ± 13.1 104.9 ± 58.7 89.1 ± 48.4 124.1 ± 64.7
Fetuin-A (U) [μg/mmol creatinine]* 8.5 ± 3.8 6.2 ± 2.9 17.5 ± 12.9 13.8 ± 9.6 21.8 ± 14.3
  1. *Data are presented as mean ± SD. ADPKD, autosomal dominant polycystic kidney disease; eGFR, estimated glomerular filtration rate; N.A., not assessed; (U), urine.
  2. **Values are in percentage. Absolute numbers are in brackets. High BP is defined as systolic BP >140 and/or diastolic BP >90 mmHg (mean of three measurements) or the need for anti-hypertensive medication.