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Table 1 Clinical characteristics and laboratory variables of patients subjected to ELISA analysis

From: Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression

 

Healthy volunteers

Renal diseases other than ADPKD

ADPKD

Total

Early

Advanced

Cases (n)

17

50

66

36

30

Age (Years)*

34.9 ± 11.1

65.3 ± 12.6

43.1 ± 17.2

31.9 ± 12.7

56.3 ± 11.5

Gender (n)**

• Male

53 (9)

66 (33)

48 (32)

50 (18)

47 (14)

• Female

47 (8)

34 (17)

52 (34)

50 (18)

53 (16)

Pathologies (n)**

• Diabetes

-

20 (10)

3 (2)

-

6 (2)

• Obesity (BMI > 30 kg/m2)

-

16 (8)

3 (2)

3 (1)

3 (1)

• Hypercholesterolemia

-

24 (12)

7 (5)

-

16 (5)

eGFR [mL/min/1.73 m2]*

N.A.

30.0 ± 15.1

71.8 ± 38.8

102.5 ± 20.6

35.4 ± 17.4

Proteinuria [g/ mmol creatinine]*

N.A.

0.621 ± 0.06

0.139 ± 0.05

0.101 ± 0.04

0.215 ± 0.02

High BP, (n)**

-

44 (22)

85 (56)

75 (27)

96 (29)

Fetuin-A (U) [μg/L]*

78.7 ± 39.5

39.2 ± 13.1

104.9 ± 58.7

89.1 ± 48.4

124.1 ± 64.7

Fetuin-A (U) [μg/mmol creatinine]*

8.5 ± 3.8

6.2 ± 2.9

17.5 ± 12.9

13.8 ± 9.6

21.8 ± 14.3

  1. *Data are presented as mean ± SD. ADPKD, autosomal dominant polycystic kidney disease; eGFR, estimated glomerular filtration rate; N.A., not assessed; (U), urine.
  2. **Values are in percentage. Absolute numbers are in brackets. High BP is defined as systolic BP >140 and/or diastolic BP >90 mmHg (mean of three measurements) or the need for anti-hypertensive medication.