From: Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression
 | Healthy volunteers | Renal diseases other than ADPKD | ADPKD | ||
---|---|---|---|---|---|
Total | Early | Advanced | |||
Cases (n) | 17 | 50 | 66 | 36 | 30 |
Age (Years)* | 34.9 ± 11.1 | 65.3 ± 12.6 | 43.1 ± 17.2 | 31.9 ± 12.7 | 56.3 ± 11.5 |
Gender (n)** | |||||
• Male | 53 (9) | 66 (33) | 48 (32) | 50 (18) | 47 (14) |
• Female | 47 (8) | 34 (17) | 52 (34) | 50 (18) | 53 (16) |
Pathologies (n)** | |||||
• Diabetes | - | 20 (10) | 3 (2) | - | 6 (2) |
• Obesity (BMI > 30 kg/m2) | - | 16 (8) | 3 (2) | 3 (1) | 3 (1) |
• Hypercholesterolemia | - | 24 (12) | 7 (5) | - | 16 (5) |
eGFR [mL/min/1.73 m2]* | N.A. | 30.0 ± 15.1 | 71.8 ± 38.8 | 102.5 ± 20.6 | 35.4 ± 17.4 |
Proteinuria [g/ mmol creatinine]* | N.A. | 0.621 ± 0.06 | 0.139 ± 0.05 | 0.101 ± 0.04 | 0.215 ± 0.02 |
High BP, (n)** | - | 44 (22) | 85 (56) | 75 (27) | 96 (29) |
Fetuin-A (U) [μg/L]* | 78.7 ± 39.5 | 39.2 ± 13.1 | 104.9 ± 58.7 | 89.1 ± 48.4 | 124.1 ± 64.7 |
Fetuin-A (U) [μg/mmol creatinine]* | 8.5 ± 3.8 | 6.2 ± 2.9 | 17.5 ± 12.9 | 13.8 ± 9.6 | 21.8 ± 14.3 |