Figure 3
From: Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression
Evaluation of Fetuin-A as a biomarker for ADPKD. (a) ELISA quantification of Fetuin-A levels normalized to creatinine in urine of ADPKD (n = 66), healthy volunteers (n = 17) and control patients with various renal diseases (n = 50). Solid lines indicate mean. (b) Evolution of urinary levels of Fetuin-A normalized to creatinine during 5 visits (V) every 6 months in 19 early ADPKD patients. Average relative change (∆, %) and p-values are indicated. (c) Urinary levels of Fetuin-A normalized to creatinine stratified by CKD stages evaluated based on eGFR values. Stage 1, eGFR = 115 ± 10 ml/min/1.73 m2 (range, 96–129), n = 23; stage 2, eGFR = 77 ± 8 ml/min/1.73 m2 (range, 61–89), n = 15; stage 3, eGFR = 45 ± 9 ml/min/1.73 m2 (range, 31–59), n = 16; stage 4, eGFR = 21 ± 2 ml/min/1.73 m2 (range, 18–25), n = 7 and stage 5, eGFR = 11 ± 1 ml/min/1.73 m2 (range, 10–14), n = 5. Solid lines indicate mean. Significance was calculated by one-way ANOVA (p = 0.023).