Figure 4

Overexpression of let-7a suppressed NPC cells proliferation, migration and invasion. (A) The growth curves determined by MTT assay showed that let-7a mimics inhibited NPC cells growth compared with negative control of let-7a. (B) Up-regulated let-7a expression dramatically decreased the ability of CNE-2 and 5-8F cells migration in vitro. (C) Elevated let-7a expression inhibited invasiveness of CNE-2 and 5-8F cells. The results were expressed as fold change relative to the corresponding blank control. Data is presented as the mean ± SD. *, P < 0.001 compared with control.