Table 1 Anti-HIV-1 activity of the compounds
From: Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains
Compound | IC50 | IC75 | IC90 | CC50 |
|---|---|---|---|---|
IIIB (X4) | ||||
ND-4040 | 1.6 | 2.3 | 3.0 | >30 |
ND-4041 | 1.9 | 5.3 | 12.6 | >30 |
ND-4042 | 0.7 | 0.9 | 1.4 | >30 |
ND-4043 | 0.6 | 0.8 | 1.0 | >30 |
4044 | >30 | >30 | >30 | 30 |
ND-4045 | >30 | >30 | >30 | 28 |
BaL (R5) | ||||
ND-4040 | 13.7 | 21.0 | 27.2 | >30 |
ND-4041 | 17.8 | >30 | >30 | >30 |
ND-4042 | 2.3 | 3.2 | 6.6 | >30 |
ND-4043 | 2.0 | 2.6 | 3.0 | >30 |
4044 | >30 | >30 | >30 | 25 |
ND-4045 | >30 | >30 | >30 | 30 |