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Table 1 Anti-HIV-1 activity of the compounds

From: Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains

Compound IC50 IC75 IC90 CC50
IIIB (X4)     
ND-4040 1.6 2.3 3.0 >30
ND-4041 1.9 5.3 12.6 >30
ND-4042 0.7 0.9 1.4 >30
ND-4043 0.6 0.8 1.0 >30
4044 >30 >30 >30 30
ND-4045 >30 >30 >30 28
BaL (R5)     
ND-4040 13.7 21.0 27.2 >30
ND-4041 17.8 >30 >30 >30
ND-4042 2.3 3.2 6.6 >30
ND-4043 2.0 2.6 3.0 >30
4044 >30 >30 >30 25
ND-4045 >30 >30 >30 30
  1. Inhibitory (50, 75 and 90%) and cytotoxic (50%) concentrations (μM) of the six compounds against X4 and R5 HIV-1 viruses in infected PBMC.