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Figure 8 | Journal of Translational Medicine

Figure 8

From: Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains

Figure 8

Breadth of anti-HIV activity by the active compounds. Fusion assays were performed with target TZM-bl cells plus donor PM1 cells chronically infected with 5 X4 (A), 5 R5 (B) and 2 R5X4 viruses (C). Each panel represents a single experiment carried out with three replicates. Fusion assays were performed in complete medium plus 2.5% of heat-inactivated FCS. The four active compounds have been tested at the indicated concentrations. Viral entry is expressed as OD/min and data are reported as mean ± SD of the three replicates. C. The p24 assay, expressed as ng/ml, was performed with day 7 supernatants from PBMC infected with the three indicated R5X4 viruses and only ND-4043 was tested (30, 10, 3 μM). Values refer to mean ± SD of three replicates.

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