Figure 7
From: Characterization of HIV-1 entry inhibitors with broad activity against R5 and X4 viral strains
Effect of compounds on entry of different viruses. A. influenza virus (flu) VLP entry in MDCK cells. ND-4041, ND-4043 and ND-4045 were tested at three concentrations; bafilomycin (100 nM) was used as positive control of flu entry inhibition. Data are expressed as percentage of control (cells in the absence of compounds) and represent mean ± SD of three replicates of two independent experiments. B. HHV-6 virus-mediated fusion of HSB-2 and TZM-bl cells. Viral entry is expressed as OD and data are mean ± SD of three replicates. ND-4043 was tested at three concentrations and the anti CD46 moAb (10, 1, 0.1 and 0.01μg/ml) was used as positive control of entry inhibition. Data are representative of two independent experiments.