Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy

Table 1 P-values of metabolite differences

A) P values of metabolite differences between resistant and sensitive tumors
P (Resist-Sens)	tCho/Cr			(GPC+PC)/Cr	Cho/Cr		tCho	GPC+PC		Cho
0d	0.001			0.003	0.005		0.026	-		0.006
1-2d	0.025			0.041	-		-	-		-
3-5d	-			-	-		-	-		0.029
6-7d	-			-	-		-	-		0.033
B) P values of metabolite differences between monitored time points after docetaxel treatment
P (time)	0d	1-2	3-5d		0d	1-2d	3-5d		0d	1-2d	3-5d
tCho/Cr	0.0009	-	0.003	(GPC+PC)/Cr	0.004	-	0.013	Cho/Cr	0.0001	-	0.006
tCho/Cr	-	0.021	-	(GPC+PC)/Cr	-	0.028	-	Cho/Cr	-	0.023	-
								Cho/Cr	-	0.041	-
tCho	0.020	-	0.033	(GPC+PC)	0.038	-	-	Cho	0.019	-	0.019

Significance of choline metabolite signal differences (p-values), corresponding with Figure 2.
A:between the resistant and sensitive tumor tissue samples of metabolite signals with respect to the creatine signal and with respect to the total integral of all signals between 2.9 and 3.6 ppm. If no number is presented the differences were not significant.
B:between the measurement time points, assessing treatment effect of the resistant and sensitive tumor tissue samples. Numbers for sensitive (regular) and resistant (italic) tumor tissue represent the p-values between the overlapping time points.

ISSN: 1479-5876