|
Cell line
|
TP53
genotype
|
p53 transcript
|
p53 protein
|
function
|
CCI-779 100 ng/ml
|
|---|
|
UT-SCC-23
|
Loss of transcript
|
-
|
-
|
-
|
95
|
|
UM-SCC-11B
|
missense mutation
|
+
|
+
|
-
|
87
|
|
UD-SCC-5
|
missense mutation
|
+
|
+
|
-
|
81
|
|
UD-SCC-4
|
delete, fs (stop codon)
|
+
|
-
|
-
|
70
|
|
UM-SCC-22B
|
missense mutation
|
+
|
+
|
-
|
64
|
|
SCC-9
|
delete, fs
|
+
|
+ (trunc.)
|
-
|
44
|
|
UM-SCC-17B
|
wt
|
+
|
+
|
+
|
38
|
|
UM-SCC-74B
|
wt
|
+
|
+
|
+
|
25
|
|
UT-SCC-15
|
Incorrectly spliced transcript, fs
|
+
|
+
|
-
|
16
|
|
UM-SCC-25
|
wt
|
(+)
|
-
|
-
|
16
|
- Cell lines were ordered by their resistance to CCI-779 at 100 ng/ml. Presented are their TP53 genotype, transcript- and protein expression. P53 function was assessed by measuring p21 and porphobilinogen deaminase (PBGD) mRNA expression before and after irradiation, using a cut-off of 1.5 fold induction.
