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Table 3 Effect of xanthine oxidase inhibition by daily oral administration of allopurinol (20 mg.kg −1 , last 4 weeks) on high fructose high fat diet- induced insulin resistance (10% fructose in drinking water plus 25% unsaturated fat in diet, for 12 weeks) associated changes in P, Q, R, S and T amplitudes

From: Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system

Treatment

P-amplitude (mV)

Q-amplitude (mV)

R-amplitude (mV)

S-amplitude (mV)

T-amplitude (mV)

Control

−0.011 ± 0.015

−0.134 ± 0.063

0.346 ± 0.077

−0.17 ± 0.07

0.053 ± 0.035

IR

0.057 ± 0.025

−0.18 ± 0.136

0.67 ± 0.148

−0.42 ± 0.21

0.14 ± 0.08

IR-Allo

0.041 ± 0.02

−0.005 ± 0.009

0.527 ± 0.085

−0.28 ± 0.07

0.155 ± 0.046

  1. Values are expressed as the mean ± S.E of mean; N = 6-8 animals; No significant differences were detected by One Way ANOVA.