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Table 2 Effect of xanthine oxidase inhibition by daily oral administration of allopurinol (20 mg.kg −1 , last 4 weeks) on high fructose high fat diet- induced insulin resistance (10% fructose in drinking water plus 25% unsaturated fat in diet, for 12 weeks) associated changes in left ventricle contractility index, heart rate, cycle duration, end systolic pressure (ESP), systolic duration and maximum pressure development (dp/dt)

From: Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system

Treatment Contractility index (1/s) Heart rate (BPM) Cycle duration (ms) ESP (mmHg) Systolic duration (s) dp/dt (mmHg/s)
Control 122.8 ± 10.88 289.4 ± 17.3 193.9 ± 6.32 87.48 ± 2.8 81.71 ± 1.79 5497 ± 626.3
IR 129.0 ± 18.21 284.5 ± 21.0 208.9 ± 13.19 109.8 ± 5.16** 80.8 ± 3.56 7428 ± 1167
IR-Allo 169.1 ± 14.6 250.4 ± 6.3 212.3 ± 9.26 110.5 ± 8.55 85.24 ± 2.92 7334 ± 720
  1. Values are expressed as the mean ± S.E of mean; N = 6-8 animals; **P < 0.01, compared with the corresponding control group values; by One Way ANOVA and Newman Keuls post hoc test.