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Table 1 Effect of xanthine oxidase inhibition by daily oral administration of allopurinol (20 mg.kg −1 , last 4 weeks) on high fructose high fat diet- induced insulin resistance (10% fructose in drinking water plus 25% unsaturated fat in diet, for 12 weeks) associated changes in body weight gain and serum levels of glucose, insulin and fructosamine and triglycerides and the insulin resistance (IR) index

From: Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system

Treatment Body weight gain (%) Glucose (mg.dl −1 ) Fructosamine (mg.dl −1 ) Insulin (μg.l −1 ) Triglycerides (mg/dl) IR index
Control 32.46 ± 5.53 72.9 ± 2.68 46.4 ± 3.26 0.77 ± 0.11 48.41 ± 2.55 3.2 ± 0.44
IR 142.2 ± 29.18** 107.8 ± 5.06*** 69.0 ± 5.67** 3.81 ± 0.7* 71.97 ± 13.17* 19.28 ± 3.29**
IR-Allo 115.5 ± 16.6 98.0 ± 3.78 62.2 ± 1.83 3.76 ± 0.85 47.49 ± 4.02# 21.87 ± 5.41
  1. Values are expressed as the mean ± S.E of mean; N = 6-8 animals; *P < 0.05, **P < 0.01, ***P < 0.001, compared with the corresponding control group values; #P < 0.05, compared with the corresponding insulin resistance group values by One Way ANOVA and Newman Keuls post hoc test.