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Table 1 Effect of xanthine oxidase inhibition by daily oral administration of allopurinol (20 mg.kg −1 , last 4 weeks) on high fructose high fat diet- induced insulin resistance (10% fructose in drinking water plus 25% unsaturated fat in diet, for 12 weeks) associated changes in body weight gain and serum levels of glucose, insulin and fructosamine and triglycerides and the insulin resistance (IR) index

From: Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system

Treatment

Body weight gain (%)

Glucose (mg.dl −1 )

Fructosamine (mg.dl −1 )

Insulin (μg.l −1 )

Triglycerides (mg/dl)

IR index

Control

32.46 ± 5.53

72.9 ± 2.68

46.4 ± 3.26

0.77 ± 0.11

48.41 ± 2.55

3.2 ± 0.44

IR

142.2 ± 29.18**

107.8 ± 5.06***

69.0 ± 5.67**

3.81 ± 0.7*

71.97 ± 13.17*

19.28 ± 3.29**

IR-Allo

115.5 ± 16.6

98.0 ± 3.78

62.2 ± 1.83

3.76 ± 0.85

47.49 ± 4.02#

21.87 ± 5.41

  1. Values are expressed as the mean ± S.E of mean; N = 6-8 animals; *P < 0.05, **P < 0.01, ***P < 0.001, compared with the corresponding control group values; #P < 0.05, compared with the corresponding insulin resistance group values by One Way ANOVA and Newman Keuls post hoc test.