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Figure 1 | Journal of Translational Medicine

Figure 1

From: A small molecule activator of AKT does not reduce ischemic injury of the rat heart

Figure 1

SC79 activates cardiac AKT. A: Dose–response experiment in normoxic perfused hearts treated with DMSO or SC79. SC79 activates AKT in a dose-dependent fashion, as demonstrated by phosphorylation at serine 473. B: Total AKT expression is not changed by SC79. C: Phosphorylation of GSK-3β at serine 9 (AKT-phosphorylated site). D: Total expression of GSK-3β. E: ATP levels are preserved in SC79-perfused hearts. F: LDH activity was not detected in SC79-treated hearts. Perfusion buffer from hearts submitted to ischemia-reperfusion (IR) were used as positive control for the LDH activity experiment. “ua/min”, units of absorbance per minute. Data are shown as mean ± standard error (SE). *, p < 0.05 vs. DMSO; &, p < 0.05 vs. all other groups.

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