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Table 2 Hypoxia-inducible factor (HIF)-regulated genes in breast cancer liver metastasis

From: Mechanisms involved in breast cancer liver metastasis

Gene HIF regulation Role in BCLM
LOX [94] HIF-1 and HIF-2 Inhibition
OPN [37,69] HIF-1 (HIF-2 not tested) Promotion
Twist [95,116] HIF-1 (HIF-2 not tested) Promotion
VEGF [95] HIF-1 and HIF-2 Promotion