Table 1 Cell adhesion molecules (CAMs) involved in breast cancer liver metastasis

Cadherins

E-cadherin

↓Breast cancer cells

Adhesion, invasion, EMT

↑Breast cancer cells [9,43,45,46]

MET

N-cadherin

↑Breast cancer cells,

Angiogenesis, EMT

↑Breast cancer cells [49]

MET

↑Endothelium cells

Integrin complexes

α2β1

↓Breast cancer cells,

Adhesion, migration, invasion, angiogenesis

↑Breast cancer cells [54]

liver metastasis, tumor angiogenesis

↑Endothelium cells

α5β1

↑Breast cancer cells,

Adhesion, migration, invasion

↑Breast cancer cells [54]

liver metastasis, tumor angiogenesis

↑Endothelium cells

Ig-SF

EpCAM

↑Breast cancer cells

Migration, invasion

↑Breast cancer cells [61]

liver metastasis

CD44

↓Breast cancer cells (CD44s);

adhesion, invasion

↑Breast cancer cells [67,68]

Liver metastasis

↑Breast cancer cells (CD44v3, CD44v4, CD44v5, CD44v6)