Skip to main content

Table 1 Cell adhesion molecules (CAMs) involved in breast cancer liver metastasis

From: Mechanisms involved in breast cancer liver metastasis

CAM family Expression in primary cancer Role Expression in BCLM Role
Cadherins     
E-cadherin ↓Breast cancer cells Adhesion, invasion, EMT ↑Breast cancer cells [9,43,45,46] MET
N-cadherin ↑Breast cancer cells, Angiogenesis, EMT ↑Breast cancer cells [49] MET
↑Endothelium cells
Integrin complexes     
α2β1 ↓Breast cancer cells, Adhesion, migration, invasion, angiogenesis ↑Breast cancer cells [54] liver metastasis, tumor angiogenesis
↑Endothelium cells
α5β1 ↑Breast cancer cells, Adhesion, migration, invasion ↑Breast cancer cells [54] liver metastasis, tumor angiogenesis
↑Endothelium cells
Ig-SF     
EpCAM ↑Breast cancer cells Migration, invasion ↑Breast cancer cells [61] liver metastasis
CD44 ↓Breast cancer cells (CD44s); adhesion, invasion ↑Breast cancer cells [67,68] Liver metastasis
↑Breast cancer cells (CD44v3, CD44v4, CD44v5, CD44v6)
  1. Note: ↑, up-regulation; ↓, down-regulation; EMT, epithelial to mesenchymal transition; MET, mesenchymal to epithelial reverting transition.