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Table 2 Comparison of studied compounds between patients with calcified aortic stenosis and without (Group A) or with (Group B) concomitant coronary atherosclerosis

From: Serum Dickkopf-1 signaling and calcium deposition in aortic valve are significantly related to the presence of concomitant coronary atherosclerosis in patients with symptomatic calcified aortic stenosis

Variable

A (N = 112)

B (N = 106)

P-value

P 1 -value

P 2 -value

P 3 - value

OPG (pmol/l);

6.06 (5.58; 6.58)

7.27 (6.74; 7.84

0.007

0.703

0.852

0.933

gmean (95% C.I.)

sRANKL (pmol/l);

121.43 (103.37; 142.64)

92.24 (73.35; 115.99)

0.238

0.787

0.860

0.977

gmean (95% C.I.)

Dkk-1 (ng/ml);

1.44 (1.25; 1.66)

1.01 (0.87; 1.17)

0.004

0.010

0.016

0.020

gmean (95% C.I.)

  1. P-value for comparison A and B.
  2. P1-value for comparison A and B after adjustment for age.
  3. P2-value for comparison A and B after adjustment for age and diabetes mellitus.
  4. P3-value for comparison A and B after adjustment for age, diabetes mellitus, hypertension, hyperlipidemia, and smoking.
  5. OPG: P-value for age < 0.001; P-value for diabetes mellitus = 0.007; P-value for hypertension = 0.949, P-value for hyperlipidemia = 0.219, P-value for smoking = 0.470.
  6. RANKL: P-value for age < 0.001; P-value for diabetes mellitus = 0.131; P-value for hypertension = 0.018, P-value for hyperlipidemia = 0.425, P-value for smoking = 0.467.
  7. OPG : RANKL Ratio: P-value for age < 0.001; P-value for diabetes mellitus = 0.018; P-value for hypertension = 0.019, P-value for hyperlipidemia = 0.244, P-value for smoking = 0.347.
  8. Dkk-1: P-value for age < 0.832; P-value for diabetes mellitus = 0.112; P-value for hypertension = 0.568, P-value for hyperlipidemia = 0.601, P-value for smoking = 0.904.
  9. gmean – geometric mean; C.I. - Confidence Interval.
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Journal of Translational Medicine

ISSN: 1479-5876

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