Effect of STC1 interferences on cell cycle. (A) (B) Knockdown of STC1 led to G1 restoration compared with negative control group in Caki-1 and A498 cells. (C) Overexpression of STC1 induced G1-S phase transition compared to empty vector group in Caki-2 cells. (D) Western blotting results for the expression alteration of several key cell cycle regulatory factors. *,P < 0.05; **,P < 0.01.