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Table 4 Performance of PAULA’s test in the combined set (training plus validation) using ROC AUC analysis of 4-biomarker MoM aggregate scores

From: Performance of a multiplexed dual analyte immunoassay for the early detection of non-small cell lung cancer

  Number of cases Cutoff AUC P value % sensitivity at 83% specificity
Early stages (I & II) 160 6.4 0.82 < 0.0001 71.2
Late stages (III & IV) 30 6.4 0.87 < 0.0001 76.7
Total 190  
Adenocarcinoma 73 6.4 0.82 < 0.0001 69.0
Squamous cell carcinoma 60 6.4 0.80 < 0.0001 70.0
Bronchioalveolar carcinoma 28 6.4 0.89 < 0.0001 85.7
Large cell (incl. LCNEC) 20 6.4 0.84 < 0.0001 75.0
Carcinoma, NOS 5 6.4 0.85 0.0069 60.0
Other 4     
Total 190