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Table 2 ROC curve area comparison

From: Performance of a multiplexed dual analyte immunoassay for the early detection of non-small cell lung cancer

A. From a logistic regression analysis
Biomarker Transformation AUC a Standard error 95% Wald Confidence Limits Probability b
Lower Upper
NY-ESO-1 Raw 0.60 0.04 0.52 0.67 0.0102
CEA Raw 0.79 0.03 0.74 0.85 <0.0001
CA125 Raw 0.70 0.03 0.63 0.77 <0.0001
CYFRA 21-1 Raw 0.69 0.04 0.62 0.76 <0.0001
4 Biomarker Modelc Raw 0.83 0.03 0.78 0.88 <0.0001
B. From a MoM analysis
Biomarker Transformation AUC a Standard error 95% Confidence Interval Probability b
Lower Upper
NY-ESO-1 Raw 0.60 0.04 0.52 0.67 0.01007
CEA Raw 0.79 0.03 0.74 0.85 <0.0001
CA125 Raw 0.70 0.03 0.63 0.77 <0.0001
CYFRA 21-1 Raw 0.69 0.04 0.62 0.76 <0.0001
4 Biomarker Modelc Raw 0.81 0.03 0.75 0.86 <0.0001
  1. aAUC.
  2. bProbability of difference to AUC = 0.5.
  3. c4 Biomarker model = NY-ESO-1, CEA, CA125, and CYFRA 21-1.