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Table 3 Comparison of GFR measurements during method A (single Iohexol bolus) and method B (CILDI)

From: Validation of a continuous infusion of low dose Iohexol to measure glomerular filtration rate: randomised clinical trial

  Creatinine Iohexol
  Plasma ( μ mol/L) Clearance (mL/min/1.73 m 2 ) Plasma clearance (mL/min/1.73 m 2 ) Renal clearance (mL/min/1.73 m 2 )
Subject A B A B A B A B
Healthy Volunteers         
1 59.7 65.7    101.9 107.4   
2 58.8 62.9    105.4 105.3   
3 52.3 61.0    100.7 102.6   
4 68.2 68.6    104.2 105.1   
5 75.0 75.5    119.3 127.7   
6 76.6 78.7 101.9 100.3 89.1 82.0 79.5 75.8
7 85.1 90.1 115.5 104.7 97.5 89.1 105.1 92.3
8 75.5 77.7 70.7 77.3 80.7 92.1   
9 55.3 57.9 120.6 112.1 83.2 83.2 78.8 87.0
10 69.6 71.4 98.7 101.0 77.9 89.4   
11 94.7 91.6 105.5 104.7 87.7 88.0 95.4 85.1
Mean ± SD 70.1 ± 13.0 72.9 ± 11.3 102.2 ± 17.5 100.0 ± 11.9 95.2 ± 12.6 97.4 ± 13.6 89.7 ± 12.8 85.1 ± 6.9
P value P = 0.59 P = 0.46 P = 0.75 P = 0.54
Chronic Kidney Disease         
12 177.0 200.2 43.8 43.9 40.7 40.5 33.7 33.4
13 219.8 215.9 38.6 36.9 33.9 38.5 27.0 23.3
14 139.3 146.8 25.8 22.8 41.3 44.3   
15 118.3 126.5 78.6 77.2 61.2 62.2 53.5 50.8
16 100.0 108.0 40.7 46.9 51.7 52.9 38.8 37.6
17 243.5 253.9 26.6 23.8 28.3 31.7 26.0 18.6
Mean ± SD 166.3 ± 57.2 175.2 ± 57.2 42.4 ± 19.3 41.9 ± 20.0 42.8 ± 12. 45.0 ± 10.9 35.8 ± 11.2 32.7 ± 12.6
P value P = 0.79 P = 0.77 P = 0.70 P = 0.70
All volunteers         
Mean ± SD 104.0 ± 58.1 109.0 ± 60.3 72.2 ± 35.8 70.9 ± 34.2 76.7 ± 28.5 78.9 ± 28.6 59.8 ± 30.5 56.0 ± 29.3
P value P = 0.81 P = 0.93 P = 0.82 P = 0.79
  1. GFR has been rounded to one decimal place. The student’s t-test was used to calculate P values comparing method A clearances with method B. CI = confidence interval, SD = standard deviation, HV = healthy volunteer, CKD = chronic kidney disease.