Table 3 Comparison of GFR measurements during method A (single Iohexol bolus) and method B (CILDI)
| Â | Creatinine | Iohexol | ||||||
|---|---|---|---|---|---|---|---|---|
|  | Plasma ( μ mol/L) | Clearance (mL/min/1.73 m 2 ) | Plasma clearance (mL/min/1.73 m 2 ) | Renal clearance (mL/min/1.73 m 2 ) | ||||
Subject | A | B | A | B | A | B | A | B |
Healthy Volunteers | Â | Â | Â | Â | Â | Â | Â | Â |
1 | 59.7 | 65.7 | Â | Â | 101.9 | 107.4 | Â | Â |
2 | 58.8 | 62.9 | Â | Â | 105.4 | 105.3 | Â | Â |
3 | 52.3 | 61.0 | Â | Â | 100.7 | 102.6 | Â | Â |
4 | 68.2 | 68.6 | Â | Â | 104.2 | 105.1 | Â | Â |
5 | 75.0 | 75.5 | Â | Â | 119.3 | 127.7 | Â | Â |
6 | 76.6 | 78.7 | 101.9 | 100.3 | 89.1 | 82.0 | 79.5 | 75.8 |
7 | 85.1 | 90.1 | 115.5 | 104.7 | 97.5 | 89.1 | 105.1 | 92.3 |
8 | 75.5 | 77.7 | 70.7 | 77.3 | 80.7 | 92.1 | Â | Â |
9 | 55.3 | 57.9 | 120.6 | 112.1 | 83.2 | 83.2 | 78.8 | 87.0 |
10 | 69.6 | 71.4 | 98.7 | 101.0 | 77.9 | 89.4 | Â | Â |
11 | 94.7 | 91.6 | 105.5 | 104.7 | 87.7 | 88.0 | 95.4 | 85.1 |
Mean ± SD | 70.1 ± 13.0 | 72.9 ± 11.3 | 102.2 ± 17.5 | 100.0 ± 11.9 | 95.2 ± 12.6 | 97.4 ± 13.6 | 89.7 ± 12.8 | 85.1 ± 6.9 |
P value | P = 0.59 | P = 0.46 | P = 0.75 | P = 0.54 | ||||
Chronic Kidney Disease | Â | Â | Â | Â | Â | Â | Â | Â |
12 | 177.0 | 200.2 | 43.8 | 43.9 | 40.7 | 40.5 | 33.7 | 33.4 |
13 | 219.8 | 215.9 | 38.6 | 36.9 | 33.9 | 38.5 | 27.0 | 23.3 |
14 | 139.3 | 146.8 | 25.8 | 22.8 | 41.3 | 44.3 | Â | Â |
15 | 118.3 | 126.5 | 78.6 | 77.2 | 61.2 | 62.2 | 53.5 | 50.8 |
16 | 100.0 | 108.0 | 40.7 | 46.9 | 51.7 | 52.9 | 38.8 | 37.6 |
17 | 243.5 | 253.9 | 26.6 | 23.8 | 28.3 | 31.7 | 26.0 | 18.6 |
Mean ± SD | 166.3 ± 57.2 | 175.2 ± 57.2 | 42.4 ± 19.3 | 41.9 ± 20.0 | 42.8 ± 12. | 45.0 ± 10.9 | 35.8 ± 11.2 | 32.7 ± 12.6 |
P value | P = 0.79 | P = 0.77 | P = 0.70 | P = 0.70 | ||||
All volunteers | Â | Â | Â | Â | Â | Â | Â | Â |
Mean ± SD | 104.0 ± 58.1 | 109.0 ± 60.3 | 72.2 ± 35.8 | 70.9 ± 34.2 | 76.7 ± 28.5 | 78.9 ± 28.6 | 59.8 ± 30.5 | 56.0 ± 29.3 |
P value | P = 0.81 | P = 0.93 | P = 0.82 | P = 0.79 | ||||