Figure 4

Effects of intraperitoneal injection of potassium 2,5-dihydroxyphenyl sulfonate (DHPS; 100 mg/kg; eq. to 0.44 mmol/kg) or potassium 2,5-diacetoxyphenyl sulfonate (DAPS; 100 mg/kg; eq. to 0.32 mmol/kg) on the lipopolysaccharide (LPS)-induced increase in tumor necrosis factor-α (TNF-α; A), interleukin-6 (IL-6; B) and interleukin-1ß (IL-1ß; C) concentrations in rat serum. Serum samples were obtained 6 h after LPS injection (5 mg/kg; i.p.) and the data are expressed as the mean ± SEM concentration of cytokine in pg/ml or ng/ml: * p < 0.05, **p < 0.01 vs. LPS + vehicle, † p < 0.05 vs. LPS+DHPS, by one-factor ANOVA followed by Student-Newmann-Keuls test.