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Table 3 SLMAP haplotype frequency and association with the risk of DR development in T2DM patients

From: Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

Haplotypes Non diabetic controls (NDC = 208) T2DM patients without DR (DNR =320) OR* (95%CI) P T2DM patients with DR (N = 156) OR8* (95% CI) P
N (%) N (%) Controls vs T2DM N (%) DNR vs DR
T rs17058639C rs1043045G rs1057719 71 (34.14) 129 (40.31) Reference 41 (26.28) Reference
C rs17058639T rs1043045A rs1057719 135 (64.90) 188 (58.75) 0.77 (0.53-1.10) 0.153 107 (68.59) 1.79 (1.17-2.74) 0.007
C rs17058639C rs1043045G rs1057719 1 (0.48) 2 (0.63) 1.10 (0.10-12.35) 0.938 7 (4.49) 11.01 (2.20-55.11) 0.004
C rs17058639C rs1043045A rs1057719 1 (0.48) 0 ND 1 (0.64) ND
Grouped analysis      
T rs17058639C rs1043045G rs1057719 71 (34.1) 129 (40.4) Reference 41 (26.3) Reference
CTA + CCG + CCA 137 (65.9) 190 (59.6) 0.76 (0.53-1.10) 115 (73.7) 1.90 (1.25-2.90) 0.003
  1. NDC = Non diabetic controls; T2DM = Type 2 Diabetes mellitus; DNR = Diabetic non-retinopathy; DR = Diabetic retinopathy; ND = not determined; *Age and gender adjusted odds ratio and p-value; significant values shown in bold.