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Table 2 Frequency distribution and association of SLMAP gene polymorphisms with T2DM/DR

From: Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

SLMAP gene polymorphisms Non diabetic controls (NDC) (N = 104) T2DM patients without DR (DNR) (N = 160) OR* (95% CI) P T2DM patients with DR (N = 78) OR* (95% CI)P
Controls vs T2DM DNR vs DR
SLMAP (rs17058639)C > T N (%) N (%)   N (%)  
TT 11 (10.6%) 29 (18.1%) Reference 6 (7.7%) Reference
CT 49 (47.1%) 71 (44.4%) 0.60 (0.26-1.39) 0.231 30 (38.5%) 2.08 (0.77-5.60) 0.146
CC 44 (42.3%) 60 (37.5%) 0.52 (0.22-1.22) 0.136 42 (53.8%) 3.23 (1.22-8.52) 0.018
TT + CT 60 (57.7%) 100 (62.5%) Reference 36 (46.2%) Reference
CC 44 (42.3%) 60 (37.5%) 0.77 (0.45-1.34) 0.357 42 (53.8%) 1.82 (1.04-3.18) 0.035
T 71 (34.1%) 129 (40.3%) Reference 42 (26.9%) Reference
C 137 (65.9%) 191 (59.7%) 0.75 (0.51-1.12) 0.160 114 (73.1%) 1.76 (1.15-2.68) 0.009
SLMAP (rs1043045)C > T      
CC 11 (10.6%) 31 (19.4%) Reference 9 (11.5%) Reference
CT 51 (49.0%) 70 (43.8%) 0.56 (0.24-1.28)0.167 31 (39.7%) 1.57 (0.66-3.73) 0.306
TT 42 (40.4%) 59 (36.9%) 0.51 (0.22-1.19) 0.120 38 (48.7%) 2.09 (0.89-4.92) 0.090
C 73 (35.1%) 132 (41.3%) Reference 49 (31.4%) Reference
T 135 (64.9%) 188 (58.8%) 0.76 (0.51-1.12) 0.162 107 (68.6%) 1.46 (0.97-2.20)0.068
SLMAP (rs1057719)A > G      
GG 11 (10.6%) 30 (18.8%) Reference 8 (10.3%) Reference
AG 50 (48.1%) 71 (44.4%) 0.59 (0.22-1.20) 0.215 32 (41.0%) 1.73 (0.71-4.23) 0.226
AA 43 (41.3%) 59 (36.9%) 0.51 (0.22-1.20) 0.125 38 (48.7%) 2.28 (0.94-5.53) 0.070
G 72 (34.6%) 131 (40.9%) Reference 48 (30.8%) Reference
A 136 (65.4%) 189 (59.1%) 0.75 (0.50-1.11) 0.150 108 (69.2%) 1.49 (0.99-2.24) 0.058
  1. NDC = Non diabetic controls; T2DM = Type 2 Diabetes mellitus; DNR = Diabetic non-retinopathy; DR = Diabetic retinopathy; *Age and gender adjusted odds ratio and p-value; significant values shown in bold.