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Table 2 Frequency distribution and association of SLMAP gene polymorphisms with T2DM/DR

From: Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

SLMAP gene polymorphisms

Non diabetic controls (NDC) (N = 104)

T2DM patients without DR (DNR) (N = 160)

OR* (95% CI) P

T2DM patients with DR (N = 78)

OR* (95% CI)P

Controls vs T2DM

DNR vs DR

SLMAP (rs17058639)C > T

N (%)

N (%)

 

N (%)

 

TT

11 (10.6%)

29 (18.1%)

Reference

6 (7.7%)

Reference

CT

49 (47.1%)

71 (44.4%)

0.60 (0.26-1.39) 0.231

30 (38.5%)

2.08 (0.77-5.60) 0.146

CC

44 (42.3%)

60 (37.5%)

0.52 (0.22-1.22) 0.136

42 (53.8%)

3.23 (1.22-8.52) 0.018

TT + CT

60 (57.7%)

100 (62.5%)

Reference

36 (46.2%)

Reference

CC

44 (42.3%)

60 (37.5%)

0.77 (0.45-1.34) 0.357

42 (53.8%)

1.82 (1.04-3.18) 0.035

T

71 (34.1%)

129 (40.3%)

Reference

42 (26.9%)

Reference

C

137 (65.9%)

191 (59.7%)

0.75 (0.51-1.12) 0.160

114 (73.1%)

1.76 (1.15-2.68) 0.009

SLMAP (rs1043045)C > T

     

CC

11 (10.6%)

31 (19.4%)

Reference

9 (11.5%)

Reference

CT

51 (49.0%)

70 (43.8%)

0.56 (0.24-1.28)0.167

31 (39.7%)

1.57 (0.66-3.73) 0.306

TT

42 (40.4%)

59 (36.9%)

0.51 (0.22-1.19) 0.120

38 (48.7%)

2.09 (0.89-4.92) 0.090

C

73 (35.1%)

132 (41.3%)

Reference

49 (31.4%)

Reference

T

135 (64.9%)

188 (58.8%)

0.76 (0.51-1.12) 0.162

107 (68.6%)

1.46 (0.97-2.20)0.068

SLMAP (rs1057719)A > G

     

GG

11 (10.6%)

30 (18.8%)

Reference

8 (10.3%)

Reference

AG

50 (48.1%)

71 (44.4%)

0.59 (0.22-1.20) 0.215

32 (41.0%)

1.73 (0.71-4.23) 0.226

AA

43 (41.3%)

59 (36.9%)

0.51 (0.22-1.20) 0.125

38 (48.7%)

2.28 (0.94-5.53) 0.070

G

72 (34.6%)

131 (40.9%)

Reference

48 (30.8%)

Reference

A

136 (65.4%)

189 (59.1%)

0.75 (0.50-1.11) 0.150

108 (69.2%)

1.49 (0.99-2.24) 0.058

  1. NDC = Non diabetic controls; T2DM = Type 2 Diabetes mellitus; DNR = Diabetic non-retinopathy; DR = Diabetic retinopathy; *Age and gender adjusted odds ratio and p-value; significant values shown in bold.