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Table 5 Univariate and multivariate analysis of prognostic factors of overall, cancer-specific and disease-free survival by Cox regression model

From: Prognostic value of pre-operative inflammatory response biomarkers in gastric cancer patients and the construction of a predictive model

Variables Overall survival Cancer-specific survival   Disease-free survival
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
HR p HR (95% CI) p HR p HR (95% CI) p HR p HR (95% CI) p
Sex (male) 0.92 0.525    0.93 0.634    0.87 0.290   
Age (≥65 years) 1.7 0.000 1.41 (1.10-1.80) 0.007 1.73 0.000 1.51 (1.16-1.96) 0.002 1.48 0.001 1.19 (0.94-1.50) 0.146
Alcohol (yes) 0.89 0.445    0.88 0.446    0.93 0.609   
Tobacco (yes) 1.24 0.160    1.27 0.133    1.15 0.336   
Family history (yes) 1.22 0.564   0.81 0.561 0.561    2.09 0.007 2.13 (1.23-3.69) 0.007
Histological type             
   Papillary 1   1   1     1    
   Non-papillary 1.83 0.061    1.77 0.093    1.89 0.038 1.42 (0.77-2.62) 0.260
   Tubular 1.54 0.213    1.51 0.263    1.58 0.166   
   Poorly differentiated 1.93 0.045 1.66 (0.86-3.19) 0.129 1.88 0.069    2.06 0.020 1.62 (0.88-3.01) 0.124
   Mucinous 1.72 0.127    1.68 0.166    1.66 0.135   
   Signetring cell 2.39 0.022 1.78 (0.83-3.79) 0.137 2.09 0.066    2.33 0.021 1.91 (0.93-3.91) 0.078
Tumor grade (G3-G4) 1.25 0.066    1.19 0.175    1.26 0.049 1.19 (0.93-1.50) 0.162
Tumor stage (III-IV) 4.87 0.000 2.18 (1.48-3.22) 0.000 5.45 0.000 2.46 (1.62-3.72) 0.000 3.58 0.000 2.04 (1.46-2.84) 0.000
Depth of invasion (T3-T4) 4.58 0.000 1.22 (0.67-2.22) 0.511 4.78 0.000 1.18 (0.63-2.21) 0.597 2.48 0.000 0.81 (0.50-1.32) 0.405
Lymph node (N1-N3) 5.6 0.000 2.34 (1.35-4.05) 0.003 5.36 0.000 2.12 (1.21-3.74) 0.009 3.05 0.000 1.39 (0.91-2.14) 0.132
Distant metastasis (M1) 4.61 0.000 2.14 (1.56-2.93) 0.000 5.07 0.000 2.09 (1.50-2.92) 0.000 3.73 0.000 2.06 (1.52-2.81) 0.000
CEA (>5 ng/ml) 1.66 0.000 0.87 (0.67-1.14) 0.323 1.74 0.000 0.93 (0.70-1.24) 0.610 1.53 0.000 0.85 (0.66-1.11) 0.237
CA199 (>37 U/ml) 1.95 0.000 1.16 (0.89-1.51) 0.275 2.14 0.000 1.30 (0.98-1.72) 0.065 1.92 0.000 1.33 (1.03-1.72) 0.028
NLR (≥2.36) 2.34 0.000 1.13 (0.68-1.87) 0.648 2.56 0.000 1.53 (1.11-2.11) 0.010 2.10 0.000 1.38 (1.04-1.82) 0.025
dNLR (≥1.85) 2.12 0.000 1.42 (1.08-1.87) 0.012 2.23 0.000 1.10 (0.66-1.85) 0.713 1.92 0.000 1.08 (0.69-1.69) 0.722
PLR (≥132) 1.51 0.001 1.03 (0.78-1.35) 0.858 1.56 0.001 0.96 (0.71-1.28) 0.763 1.42 0.003 0.94 (0.72-1.23) 0.674
LMR (≥4.95) 0.49 0.000 1.00 (0.73-1.35) 0.977 0.44 0.000 1.00 (0.71-1.40) 0.995 0.55 0.000 0.98 (0.73-1.32) 0.907
  1. HR, hazard ratio; CI, confidence interval; NLR, neutrophil count to lymphocyte count; dNLR, neutrophil count to (white cell count – neutrophil count); PLR, platelet count to lymphocyte count; LMR, lymphocyte to monocyte ratio.
  2. aGrade 1 and 2 stand for high or middle differentiated tumor, grade 3 and 4 stand for poorly differentiated tumor.
  3. bTumor stage according to seventh edition of American Joint of Committee on Cancer.