Variables | Overall survival | Cancer-specific survival | Â | Disease-free survival | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||
HR | p | HR (95% CI) | p | HR | p | HR (95% CI) | p | HR | p | HR (95% CI) | p | |
Sex (male) | 0.92 | 0.525 | Â | Â | 0.93 | 0.634 | Â | Â | 0.87 | 0.290 | Â | Â |
Age (≥65 years) | 1.7 | 0.000 | 1.41 (1.10-1.80) | 0.007 | 1.73 | 0.000 | 1.51 (1.16-1.96) | 0.002 | 1.48 | 0.001 | 1.19 (0.94-1.50) | 0.146 |
Alcohol (yes) | 0.89 | 0.445 | Â | Â | 0.88 | 0.446 | Â | Â | 0.93 | 0.609 | Â | Â |
Tobacco (yes) | 1.24 | 0.160 | Â | Â | 1.27 | 0.133 | Â | Â | 1.15 | 0.336 | Â | Â |
Family history (yes) | 1.22 | 0.564 | Â | 0.81 | 0.561 | 0.561 | Â | Â | 2.09 | 0.007 | 2.13 (1.23-3.69) | 0.007 |
Histological type | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   Papillary | 1 |  | 1 |  | 1 |  |  |  | 1 |  |  |  |
   Non-papillary | 1.83 | 0.061 |  |  | 1.77 | 0.093 |  |  | 1.89 | 0.038 | 1.42 (0.77-2.62) | 0.260 |
   Tubular | 1.54 | 0.213 |  |  | 1.51 | 0.263 |  |  | 1.58 | 0.166 |  |  |
   Poorly differentiated | 1.93 | 0.045 | 1.66 (0.86-3.19) | 0.129 | 1.88 | 0.069 |  |  | 2.06 | 0.020 | 1.62 (0.88-3.01) | 0.124 |
   Mucinous | 1.72 | 0.127 |  |  | 1.68 | 0.166 |  |  | 1.66 | 0.135 |  |  |
   Signetring cell | 2.39 | 0.022 | 1.78 (0.83-3.79) | 0.137 | 2.09 | 0.066 |  |  | 2.33 | 0.021 | 1.91 (0.93-3.91) | 0.078 |
Tumor grade (G3-G4) | 1.25 | 0.066 | Â | Â | 1.19 | 0.175 | Â | Â | 1.26 | 0.049 | 1.19 (0.93-1.50) | 0.162 |
Tumor stage (III-IV) | 4.87 | 0.000 | 2.18 (1.48-3.22) | 0.000 | 5.45 | 0.000 | 2.46 (1.62-3.72) | 0.000 | 3.58 | 0.000 | 2.04 (1.46-2.84) | 0.000 |
Depth of invasion (T3-T4) | 4.58 | 0.000 | 1.22 (0.67-2.22) | 0.511 | 4.78 | 0.000 | 1.18 (0.63-2.21) | 0.597 | 2.48 | 0.000 | 0.81 (0.50-1.32) | 0.405 |
Lymph node (N1-N3) | 5.6 | 0.000 | 2.34 (1.35-4.05) | 0.003 | 5.36 | 0.000 | 2.12 (1.21-3.74) | 0.009 | 3.05 | 0.000 | 1.39 (0.91-2.14) | 0.132 |
Distant metastasis (M1) | 4.61 | 0.000 | 2.14 (1.56-2.93) | 0.000 | 5.07 | 0.000 | 2.09 (1.50-2.92) | 0.000 | 3.73 | 0.000 | 2.06 (1.52-2.81) | 0.000 |
CEA (>5Â ng/ml) | 1.66 | 0.000 | 0.87 (0.67-1.14) | 0.323 | 1.74 | 0.000 | 0.93 (0.70-1.24) | 0.610 | 1.53 | 0.000 | 0.85 (0.66-1.11) | 0.237 |
CA199 (>37 U/ml) | 1.95 | 0.000 | 1.16 (0.89-1.51) | 0.275 | 2.14 | 0.000 | 1.30 (0.98-1.72) | 0.065 | 1.92 | 0.000 | 1.33 (1.03-1.72) | 0.028 |
NLR (≥2.36) | 2.34 | 0.000 | 1.13 (0.68-1.87) | 0.648 | 2.56 | 0.000 | 1.53 (1.11-2.11) | 0.010 | 2.10 | 0.000 | 1.38 (1.04-1.82) | 0.025 |
dNLR (≥1.85) | 2.12 | 0.000 | 1.42 (1.08-1.87) | 0.012 | 2.23 | 0.000 | 1.10 (0.66-1.85) | 0.713 | 1.92 | 0.000 | 1.08 (0.69-1.69) | 0.722 |
PLR (≥132) | 1.51 | 0.001 | 1.03 (0.78-1.35) | 0.858 | 1.56 | 0.001 | 0.96 (0.71-1.28) | 0.763 | 1.42 | 0.003 | 0.94 (0.72-1.23) | 0.674 |
LMR (≥4.95) | 0.49 | 0.000 | 1.00 (0.73-1.35) | 0.977 | 0.44 | 0.000 | 1.00 (0.71-1.40) | 0.995 | 0.55 | 0.000 | 0.98 (0.73-1.32) | 0.907 |