| |
Mutational status of tumor
|
PFS (Days)
|
PI3K (% change)
|
pPI3K (% change)
|
IGF1R (% change)
|
pMEK (% change)
|
cMET (% change)
|
pERK (% change)
|
pAKT (% change)
|
|---|
| |
BRAF
|
385
|
-99.5
|
-97.1
|
-93.6
|
-
|
-72.3
|
-
|
-83.9
|
| |
Wt
|
275
|
-46.3
|
-75.3
|
-61
|
-92.9
|
-75.8
|
-96.8
|
-90.4
|
| |
KRAS + PIK3CA
|
274
|
-39.7
|
54.9
|
0
|
0
|
378.7
|
1570
|
2653.9
|
| |
Wt
|
252
|
-97.7
|
0
|
-59.3
|
0
|
-86
|
-93.3
|
-61.5
|
| |
Wt
|
484
|
-86
|
-86.8
|
-95.3
|
0
|
-97.1
|
-87.5
|
210
|
| |
Wt
|
236
|
-63.2
|
-96.7
|
-99.4
|
-94.2
|
-73.1
|
-98.1
|
-98.7
|
| |
Wt
|
109
|
-99.8
|
0
|
59.1
|
0
|
1261
|
30.6
|
-64.3
|
| |
BRAF
|
106
|
483.3
|
97.3
|
1630
|
0
|
473.3
|
540
|
975
|
| |
NRAS
|
106
|
-92.7
|
-96.8
|
-97.2
|
-92.5
|
-93.5
|
-99
|
-64.3
|
| |
KRAS + PIK3CA
|
105
|
-99.9
|
0
|
0
|
0
|
1864.5
|
0
|
-81.8
|
| |
KRAS
|
48
|
36020
|
-38.3
|
38.6
|
730
|
561.7
|
1490
|
2653.9
|
| |
KRAS
|
47
|
180
|
770
|
7.6
|
-37.1
|
324.8
|
1.3
|
571
|
| |
BRAF + KRAS
|
49
|
159.7
|
-96.5
|
12.7
|
-94.2
|
20
|
-81.6
|
-97.5
|
| |
PIK3CA + NRAS
|
49
|
-85.7
|
-99.6
|
-99.9
|
-97.6
|
-86.4
|
-96.2
|
-81.3
|
|
*Test of null hypothesis P value
| | |
0.01
|
0.50
|
0.12
|
0.57
|
0.07
|
0.53
|
0.70
|
- Wt – Wild-type.
- Negative % change reflects downregulation; positive % change reflects upregulation.
- *Mann Whitney U test (2-tailed) of PFS between patient populations with upregulated or downregulated protein expression.
