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Figure 4 | Journal of Translational Medicine

Figure 4

From: Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib

Figure 4

Immunohistochemistry of selected proteins of representative samples before and after regorafenib treatment. Patient 27: pVEGFR2 staining shoes a reduced H score of pre-trearment-35 (A1: 5% 2+; 30% 1 + staining) to post-treatment-20 (A2: 5% 2+; 15% 1+ staining) in a small proportion of tumor cells. Arrows denote reduced proportion of tumor cells with 1+ staining between pre and post-treatment samples. Patient 20: Ki67 staining shows reduced expression of pre-treatment (B1: 63%) to post-treatment (B2: 26%); pAKT staining shows a reduced H score of pre-treatment-10 (C1: 6% 3+; 2% 2+; 2% 1+; 90% 0) to post-treatment (C2: 2% 3+; 8% 2+; 10% 1+; 80% 0); pcMET staining shows an increased H score of pre-treatment-80 (D1: 0% 3+; 2%+; 78% 1+; 20% 0) to post-treatment -95 (D2: 20% 3+; 5% 2+; 70% 1 + 5% 0); pJUN staining shows an increased H score of pre-treatment-5 (E1: 0% 3+; 0% 2+; 5% 1+; 95% 0) to post-treatmetn-50 (E2: 2% 3+; 13% 2+; 35% 1+; 50% 0); pSRC staining shows an increased H score of pre-treatmetn-3 (F1: )% 3+; 0% 2+; 3% 1+; 97% 0) to post-treatment-35 (F2: 15% 3+; 10% 2+; 10% 1+; 65% 0). Only staining in tumor cells was scored, background and stromal staining was ignored.

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