Effects of GRK5 and ADRB1 polymorphisms influence on systolic heart failure

Table 2 Clinical analysis in multivariable clinical model

Variable	OR	95% CI	P value
Age	1.123	1.074 to 1.174	0.000
Male gender	1.166	0.321 to 4.231	0.851
BMI	0.983	0.942 to 1.026	0.435
Heart rate	1.029	1.003 to 1.055	0.025
Smoking	2.734	1.026 to 7.291	0.044
Drinking	1.287	0.908 to 1.824	0.157
Hypertension	3.277	2.500 to 4.296	0.000
Diabetes mellitus	1.844	1.102 to 3.085	0.020
Coronary heart disease	9.702	6.056 to 15.543	0.000
Valvular heart disease	8.107	4.594 to 14.307	0.000
Chronic renal disease	2.045	1.140 to 3.668	0.016
Glycosylated hemoglobin	1.083	1.009 to 1.163	0.027
Hs-CRP	1.087	1.048 to 1.128	0.000
GRK5	2.377	0.237 to 23.870	0.872
GRK5
Gln41Gln	Reference	Reference
Gln41Leu	2.219	0.216 to 22.812	0.503
ADBR1	1.121	0.608 to 2.064	0.715
ADRB1
Arg389Arg	Reference	Reference
Arg389Gly	1.478	0.638 to 3.424	0.362
Gly389Gly	0.820	0.157 to 4.284	0.814

Note: Significant factors (p < 0.05) for the risk of SHF. BMI, body mass index (kilogram/meter²) = weight/height²; CI, confidence interval; Hs-CRP (mg/L), high-sensitivity C-reactive protein; OR, odd ratio; other abbreviations as in Table 1. GRK5 and ADRB1 polymorphisms were respectively analyzed as numerical variables and categorical variables for the risk of SHF morbidity.

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