From: Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas
Sample | BRAF | NRAS | BRAF + PIK3CA | NRAS + PIK3CA | PIK3CA | Wild-type |
---|---|---|---|---|---|---|
% | % | % | % | % | % | |
Primary melanoma (N = 212) | 81 | 21 | 9 | 1 | 10 | 90 |
38.2 | 9.9 | 4.2 | 0.5 | 4.7 | 42.5 | |
Melanoma cell line (N = 33) | 18 | 4 | 2 | 0 | 2 | 7 |
54.5 | 12.1 | 6.1 | 0 | 6.1 | 21.2 | |
Total (N = 245) | 99 | 25 | 11 | 1 | 12 | 97 |
40.4 | 10.2 | 4.5 | 0.4 | 4.9 | 39.6 |