Table 2 Reported AEs (all grades) ^a during treatment with NHS-IL2 in advanced-stage NSCLC patients, deemed treatment related

General disorders, n (%)

Anorexia

3 (100.0)

-

2 (28.6)

5 (38.5)

Fatigue

3 (100.0)

2 (66.7)

2 (28.6)

7 (53.8)

Fever

2 (66.7)

2 (66.7)

-

4 (30.8)

Flu-like illness

-

-

3 (42.9)

3 (23.1)

Malaise

-

-

2 (28.6)

2 (15.4)

Blood and lymphatic system disorders, n (%)

Lymphopenia^b

-

-

1 (14.3)

1 (7.7)

Normochromic normocytic anemia^b

-

1 (33.3)

-

1 (7.7)

Gastrointestinal symptoms, n (%)

Abdominal pain upper

2 (66.7)

-

-

2 (15.4)

Diarrhea

-

1 (33.3)

1 (14.3)

2 (15.4)

Eructation

2 (66.7)

-

-

2 (15.4)

Nausea

2 (66.7)

-

1 (14.3)

3 (23.1)

Stomatitis

1 (33.3)

-

1 (14.3)

2 (15.4)

Respiratory symptoms, n (%)

Dyspnea

1 (33.3)

1 (33.3)

2 (28.6)^b

4 (30.8)

Productive cough

1 (33.3)

-

1 (14.3)

2 (15.4)

Skin disorders, n (%)

Dry skin

-

2 (66.7)

2 (28.6)

4 (30.8)

Pruritus

1 (33.3)

1 (33.3)

1 (14.3)

3 (23.1)

Facial/periorbital edema^c

-

1 (33.3)

1 (14.3)

2 (15.4)

Peripheral edema

-

1 (33.3)

2 (28.6)

3 (23.1)

Rash (any)

1 (33.3)

2 (66.7)

3 (42.9)

6 (46.2)

  Erythema

1 (33.3)

1 (33.3)

2 (28.6)

4 (30.8)

  Rash maculopapular

1 (33.3)

1 (33.3)

1 (14.3)

3 (23.1)

  Exfoliative rash

-

1 (33.3)

1 (14.3)

2 (15.4)

Other, n (%)

Atrial fibrillation

-

-

2 (28.6)

2 (15.4)

Dry eye

-

1 (33.3)

1 (14.3)

2 (15.4)

Hyperthyroidism

-

2 (66.7)

1 (14.3)

3 (23.1)

Pericarditis malignant^b

-

-

1 (14.3)

1 (7.7)