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Table 3 Univariate and multivariate analysis of Cezanne associated with survival and recurrence in HCC patients

From: Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma

Variables* OS TTR
Univariate Multivariate Univariate Multivariate
P -value P -value HR 95% CI P -value P -value HR 95% CI
Gender (Female vs. Male) NS NS    NS NS   
Age, years (≤50 vs. > 50) NS NS    NS NS   
AFP (ng/mL) (≤20 vs. > 20) 0.016 NS    0.049 NS   
HBsAg (Negative vs. Positive) NS NS    NS NS   
GGT (U/l) (≤50 vs. > 50) 0.001 NS    0.006 NS   
Liver cirrhosis (No vs. Yes) 0.006 0.008 2.216 1.232-3.985 0.012 0.017 1.865 1.115-3.117
Tumor size (cm) (≤5 vs. > 5) <0.001 0.032 1.616 1.042-2.504 <0.001 0.004 1.866 1.222-2.849
Tumor number (Single vs. Multiple) NS NS    0.025 NS   
Satellite nodule (No vs. Yes) NS NS    0.009 NS   
Tumor capsule (No/incomplete vs. Complete) NS NS    NS NS   
Tumor differentiation (I-II vs. III-IV) NS NS    NS NS   
Vascular invasion (No vs. Yes) <0.001 <0.001 2.941 1.706-5.072 <0.001 <0.001 2.471 1.475-4.138
Cezanne (Low versus High) <0.001 <0.001 0.352 0.226-0.546 <0.001 <0.001 0.354 0.237-0.528
  1. *TNM stage and BCLC stage was combined with several clinical indexes such as tumor size, number and tumor thrombus; we did not enter the TNM stage and BCLC stage into multiple analysis with these indexes to avoid any bias in analysis.
  2. GGT gamma-glutamyltransferase, AFP α-fetoprotein, OS overall survival, TTR time to recurrence, NS not significant, HR hazard ratio, CI confidential interval.