Association between antibody against RPA2 and other clinical parameters. The antibody levels against RPA2 weakly correlated with age (*r2 = 0.113, P < 0.05). Correlation was examined between RPA2-Abs and age (A), gender (B), hypertention (C), diabetes (D), hyperlipidemia (E), smoking (F), ischemic stroke (G), stroke subtype (H), intracranial stenosis (I), infarct size (J) and period between the onset and blood sampling (K). The elevated antibody levels were observed in patients with hypertension and ischemic stroke (*P < 0.05 by Mann–Whitney U test). RPA2-Abs, RPA2 antibodies. LAA, large artery atherosclerosis. SVD, small vessel disease. CE, cardioembolism. HD, healthy donor.