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Table 4 CTL optimal epitopes and CD4 + T-helper epitope coverage of HTI

From: A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Protein location # of CTL epitopes a # of CD4 + T Helper Gag epitopes (>25% targeted) b # of ‘promiscuous’ CD4 + T cell Gag peptides c
Gag-p17 17 3 6
Gag-p24 21 2 6
Gag-p15 3 1 2
Pol-Prt 5   
Pol-RT 6   
Pol-Int 1   
Vif 2   
Nef 0   
Total 55 6 14
  1. abased on the ‘A’ list of optimal defined HIV-1 CTL epitopes described in the Los Alamos HIV Immunology Database [55].
  2. b,cdescribed CD4 T-helper epitopes [7,53].