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Table 4 CTL optimal epitopes and CD4 + T-helper epitope coverage of HTI

From: A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Protein location

# of CTL epitopes a

# of CD4 + T Helper Gag epitopes (>25% targeted) b

# of ‘promiscuous’ CD4 + T cell Gag peptides c

Gag-p17

17

3

6

Gag-p24

21

2

6

Gag-p15

3

1

2

Pol-Prt

5

  

Pol-RT

6

  

Pol-Int

1

  

Vif

2

  

Nef

0

  

Total

55

6

14

  1. abased on the ‘A’ list of optimal defined HIV-1 CTL epitopes described in the Los Alamos HIV Immunology Database [55].
  2. b,cdescribed CD4 T-helper epitopes [7,53].