Design of HTI, HLA coverage and translation into HIV-1 control. (A) HLA supertype coverage of all the optimal defined epitopes included in HTI immunogen . Colors are based on the allele’s reported relative hazard to develop AIDS (grey, neutral; black, neutral/rapid progression; white, beneficial) [57,58]. (B) The relative dominance of the responses induced by OLP covering the HTI sequence (n = 52) to the complete HIV-1 proteome (n = 410) is shown in elite controllers (EC, n = 38), viremic controllers (VC, n = 27) and non-controllers (NC, n = 30). (C) Total IFN-γ ELISPOT responses (magnitude) against the complete HIV-1 proteome elicited by consensus B overlapping 18-mer peptide sets (n = 410).