The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

Table 3 Risk factors associated with carotid intima media thickness (cIMT) using univariable and multivariable models

Predictors	Co-efficient (95% confidence interval)	p-value
Univariable model
Age, years	0.007 (0.004, 0.011)	<0.001*
Body mass index, kg/m²	0.006 (-0.005, 0.017)	0.273
Total cholesterol, mmol/L	0.015 (-0.021, 0.051)	0.415
Triglyceride, mmol/L	0.003 (-0.029, 0.029)	0.985
HDL, mmol/L	-0.001 (-0.105, 0.103)	0.984
LDL, mmol/L	0.019 (-0.022, 0.060)	0.369
Fasting glucose, mmol/L	-0.017 (-0.053, 0.020)	0.366
Framingham score, %	0.011 (0.006, 0.016)	<0.001
Baseline CD4 T-cell counts, per 100 cells/μl	-0.011 (-0.044, 0.022)	0.527
Log baseline HIV RNA	-0.006 (-0.028, 0.016)	0.585
Log current CD4 T-cell counts	0.043 (-0.016, 0.104)	0.151
Log sCD14	0.020 (-0.083, 0.123)	0.700
Log sCD163	-0.054 (-0.135, 0.027)	0.190
Log hsCRP	0.0005 (-0.025, 0.026)	0.970
CD14 C-260T genotype; CC/CT vs TT	-0.013 (-0.099, 0.071)	0.758
Multivariable model
Framingham score, %	0.009 (0.004, 0.014)	<0.001
Log current CD4 T-cell counts	0.038 (-0.033, 0.108)	0.289
Log sCD163	-0.084 (-0.182, 0.013)	0.087

*Age was omitted from the multivariable model given that it is one of the components used to derive the Framingham risk score.

ISSN: 1479-5876