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Table 2 Comparison of markers of immune activation, inflammation and cardiovascular risk factors among the CD14 C-260T CC/CT vs TT carriers

From: The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

 

CC/CT (n = 56) *

TT (n = 24) *

p

p Δ

Immune activation and inflammatory markers

  

Log sCD14

6.20 (6.11–6.28)

6.24 (6.15–6.30)

0.266§

0.188

Log sCD163

2.94 (2.84–3.07)

3.03 (2.97 3.20)

0.008§

0.013

Log hsCRP

-0.77 (-0.32 - -1.08)

-0.53 (-0.26 - -0.95)

0.296§

0.232

Cardiovascular risk factors

    

Body mass index, kg/m2

22.4 (20.9–25.2)

23.9 (20.6–26.0)

0.482§

 

Fasting sugar, mmol/L

5.0 (4.6–5.5)

5.1 (4.6–5.8)

0.298§

 

Total cholesterol, mmol/L

5.2 (4.6–6.0)

5.1 (4.8–5.6)

0.858§

 

Triglyceride, mmol/L

1.8 (1.4–2.3)

2.0 (1.5–2.8)

0.239§

 

HDL, mmol/L

1.24 (0.99–1.49)

1.12 (0.90–1.31)

0.087§

 

LDL, mmol/L

2.9 (2.5–3.8)

3.1 (2.6–3.5)

0.978§

 

Age, years

41 (36–46)

41 (36–48)

0.961§

 

Male gender, %

82.1%

70.8%

0.257#

 

Current smoker, %

30.4%

33.3%

0.792#

 

Framingham risk score

5.05 (2.80–9.08)

4.75 (2.23–14.80)

0.925§

 
  1. *Data shown are median (IQR) unless otherwise stated; §p-value for Mann-Whitney U; #p-value for Chi-square test; Δp-value adjusted for smoking status, current CD4 T-cell counts, age and gender.