Figure 2

ATX preserves renal function and histology after IR. ( A-B) Circulating levels of urea nitrogen (BUN) and creatinine (Cr) in different experimental groups (n = 6 in each group). (C) Representative images of HE staining of kidney sections in each experimental groups, showing significantly higher degree of tubular damage including tubular necrosis (yellow arrow), cast formation (green asterisk), dilatation of tubules (red asterisk), loss of brush border (yellow asterisk) in IR group. Please note that dilatation of Bowman’s capsule (red arrow), and accumulation of red blood cells in tubules (green arrow) could also be observed in IR groups, suggesting the damage to glomerular. (D) Results of total histopathological scores reflecting tubular damage in each group. *, P < 0.05 compared with IR group.