Table 2 Clinical trials of siRNA therapy in kidney diseases
From: Fighting against kidney diseases with small interfering RNA: opportunities and challenges
Study | Target/siRNA drug | Status | Disease |
|---|---|---|---|
NCT00554359 | I5NP | Phase I, completed | Kidney injury; Acute renal failure |
NCT00802347 | I5NP | Phase I/II, active, not recruiting | Delayed graft function in kidney transplantation |
NCT00689065 | M2 subunit of ribonucleotide reductase/CALAA-01 | Phase I, terminated | Solid tumor cancers |
NCT02166255 | siRNA-transfected peripheral blood mononuclear cells APN401 | Phase I, not yet recruiting | Melanoma, kidney cancer, pancreatic cancer, or other solid tumors that are metastatic or cannot be removed by surgery |