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Table 2 Clinical trials of siRNA therapy in kidney diseases

From: Fighting against kidney diseases with small interfering RNA: opportunities and challenges

Study Target/siRNA drug Status Disease
NCT00554359 I5NP Phase I, completed Kidney injury; Acute renal failure
NCT00802347 I5NP Phase I/II, active, not recruiting Delayed graft function in kidney transplantation
NCT00689065 M2 subunit of ribonucleotide reductase/CALAA-01 Phase I, terminated Solid tumor cancers
NCT02166255 siRNA-transfected peripheral blood mononuclear cells APN401 Phase I, not yet recruiting Melanoma, kidney cancer, pancreatic cancer, or other solid tumors that are metastatic or cannot be removed by surgery