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Table 1 Studies on kidney diseases using siRNAs

From: Fighting against kidney diseases with small interfering RNA: opportunities and challenges

Investigators Model Modification Transfection Delivery Target gene Pathway Reference
Yang et al. Porcine LLC-PK1 - Cationic lipid In vitro Caspase-3 Apoptosis [25]
Yang et al. Porcine - UW solution Ex vivo, renal artery injection and autologous blood perfusate Caspase-3 Apoptosis [22]
Yang et al. Porcine - UW solution In vivo, renal artery injection Caspase-3 Apoptosis [14]
Yang et al. Porcine LNA UW solution In vivo, renal artery injection and systemically iv. Caspase-3 Apoptosis [18]
Liu et al. Mice - Plasmid In vivo, hydrodynamic injection iv. TLR9 Innate immunity [48]
Hamar et al. Mice 2’-O-ACE-RNA phosphoramidites Phosphate buffered saline In vivo, hydrodynamic injection iv. Fas Apoptosis [28]
Wan et al. Rats - Phosphate buffered saline In vivo, renal artery injection IKKβ Inflammation [27]
Xia et al. Mice - Cationized gelatin microspheres In vivo, injected via ureter HSP47 collagen-producing, fibrosis [29]
Molitoris et al. Rats 2’O-methylation Lipofectamine 2000 In vivo, iv. p53 Apoptosis [37]
Zheng et al. Mice - Lipofectamine 2000 In vivo, hydrodynamic injection iv. Complement 3 and caspases-3 Complement and apoptosis [38]
Shimizu et al. Mice - Nanocarrier complexation In vivo, ip. MAPK1 Immunity [49]
Shang et al. ACHN, A498 RCC cells - Lipofectamine 2000 In vitro HIF-1α, HIF-2α Tumorigenesis [53]
Juengel et al. Caki-1 RCC cells - Transfection reagent supplied by Qiagen In vitro HDAC1, HDAC2 Acetylation [54]
Fujino et al. Mice - Cationic lipid In vivo, renal artery injection p53 Apoptosis [46]
  1. UW: University of Wisconsin; TLR: toll-like receptor; siSTABLE: stability-enhanced siRNA; RCC: renal cell carcinoma; MAPK1: mitogen-activated protein kinase 1; HIF: hypoxia induced factor; HDAC: histone deacetylases.