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Table 2 Transcriptomics analysis by IPA showed the up-regulation of several genes in ECs Mes that are involved in EMT/EndMT processes some of which are listed in the table

From: Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche

Gene name

Function

Fold change

Refs

S100A4 (FSP1)

Mesenchymal marker

+2.54

[1,17,18]

Jagged1

Notch signaling ligand

+2.31

[32-34]

Notch2

Jagged1 receptor

+2.12

[32-34]

HEY1

Notch effector

+2.64

[62,63]

HES4

Notch effector

+2.1

[62,63]

TGFBI

Involvement in EMT

+2.93

[18,30,31,34]

BMPR1A

TGFβ/Smad receptor

+2.80

[34,35]

EGFR

EMT inducer

+3.78

[64,65]

WNT5B

EMT inducer

+2.23

[66-68]

HMGA2

EMT-inducing transcribtion factor

+2.13

[69-71]

IGFBP2

EMT-inducing signaling

+13.12

[72,73]

STAT2

EMT-inducing signaling

+3.1

[72,74]