across three groups of the rats. (A) Levels of MRAK052686 and Nrf2 expression in livers were measured by RT-qPCR and normalized by β-actin expression. Significance was assessed by one-way ANOVA followed by Tukey’s multiple comparison tests. Data are shown as mean ± SEM (n ≥ 4). Pearson’s correlation coefficient (R) and corresponding p value of the fitted line are shown in (B).