Figure 8

Protein expressions of fibrotic and anti-fibrotic biomarkers in ischemic quadriceps on day 14 following critical limb ischemia (CLI) procedure (n =  8). A) Protein expression of transforming growth factor (TGF)-β in four groups (SC = sham control; SC + Lc-MPs = sham control + lung-cancer patient-derived microparticles; CLI = critical limb ischemia; CLI + Lc-MPs = critical limb ischemia + lung-cancer patient-derived microparticles), * vs. other groups with different symbols (*, †, ‡), p < 0.001. B) Protein expression of phosphorylated (p)-Smad3 in four groups, * vs. other groups with different symbols (*, †, ‡), p < 0.01. C) Protein expression of bone morphogenetic protein (BMP)-2 in four groups, * vs. other groups with different symbols (*, †, ‡), p < 0.001. D) Protein expression of p-Smad1/5 in four groups, * vs. other groups with different symbols (*, †, ‡), p < 0.01. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (*, †, ‡) indicate significance (at 0.05 level).