Figure 6

Bioinformatic analysis of the differentially expressed proteins. A. Predicted interaction network of the differentially expressed proteins and their putative functional partners. The proteins were analyzed using the STRING database 9.0. Nodes represent proteins. The predicted functional interaction networks are shown in the action view where the different associations are represented by differently colored lines. Each interaction between nodes is supported by the literature. APOE - apolipoprotein E; HP - haptoglobin; TTR – transthyretin; C4A13 -complement C4A; AMBP - α-1 m; ITIH4 - inter alpha-trypsin inhibitor H4; FGG – Fb gamma; APOA4 – apolipoprotein A4; C6orf127 - transmembrane and coiled-coil domain-containing protein, FGA - fibrinogen alpha chain, FGB - fibrinogen beta chain, LCAT- lecithin-cholesterol acyltransferase, LIPC - lipase, hepatic, ABCA1 - ATP-binding cassette, sub-family A (ABC1), F2 - coagulation factor II (thrombin), LDLR - low density lipoprotein receptor, APOA2 - apolipoprotein A-II, RBP4 – retinol-binding protein 4, APOC3 - apolipoprotein C-III. B, C. Classification of the identified differentially expressed proteins in molecular function (B) and biological processes (C) on the basis of gene ontology (GO) annotations. * indicate processes with p value below 0.05.