Prognostic significance of cytoplasmic S100A2 overexpression in oral cancer patients

Table 3 Cox regression analyses

Predictors	Test set (n = 162)			Internal validation of test set*			External validation set (n = 102)
Predictors	HR [95% CI]	p	c-statistic	HR [95% CI]	p	c-statistic	HR [95% CI]	p	c-statistic
Univariate analyses
Cyto S100A2 % Pos	1.35 [1.09, 1.67]	<0.01	0.59	1.35 [1.10, 1.76]	0.01	0.59^€	1.40 [1.04, 1.90]	0.03	0.60
Multivariable analyses adjusted for clinical parameters
Cyto S100A2 % Pos	1.33 [1.07, 1.65]	0.01	0.62	1.34 [1.08, 1.78]	0.03	0.59^€	1.47 [1.07, 2.03]	0.02	0.67
Histology grade	1.32 [0.91, 1.91]	0.14		1.32 [0.90, 1.92]	0.14		1.03 [0.65, 1.64]	0.90
Clinical stage	1.06 [0.60, 1.89]	0.83		1.07 [0.59, 1.93]	0.84		1.00 [0.65, 1.54]	0.99
Nodal status	1.30 [0.68, 2.51]	0.43		1.33 [0.69, 2.82]	0.45		2.09 [0.89, 4.92]	0.09
Tumor stage	1.10 [0.72, 1.70]	0.65		1.11 [0.71, 1.77]	0.67		1.23 [0.86, 1.78]	0.25

^*Internal validations were based on 9999 bootstrap samples; ^€Optimism corrected c-statistic.

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