Figure 2

Growth factor ratio of Mstn/IGF-I (A), receptor ratio of ActRIIB/IGF-IR (B) and ‘Mstn/IGF-I signaling index’ (C) in the septum (S), left ventricles (LV) and right ventricles (RV) of control (CONT)-, DCM-, and ICM hearts, respectively. Panel C represents the ratio of Mstn and IGF-I signaling referred to as ‘Mstn/IGF-I signaling index’ (‘Mstn signaling index’ divided by ‘IGF-I signaling index’ (Mstn x ActRIIB)/(IGF-I x IGF-IR)). Data are expressed in mean ± SEM, asterisks show significant differences (n = 5, *p < 0.05, **p < 0.01, ***p < 0.001).