Figure 1

Gene expression levels of Mstn and IGF-I as well as their receptors ActRIIB and IGF-IR normalized to HPRT in the septum (S), left ventricles (LV) and right ventricles (RV) of control (CONT)-, DCM-, and ICM hearts, respectively. Bars represent normalized Mstn- (A), ActRIIB- (B), IGF-I- (D), and IGF-IR- (E) transcript levels. Panel C shows ‘Mstn signaling index’ (Mstn multiplied by ActRIIB mRNA levels) while panel F represents ‘IGF-I signaling index’ (IGF-I multiplied by IGF-IR mRNA levels). Data are expressed in mean ± SEM, asterisks show significant differences (n = 5, *p < 0.05, **p < 0.01).