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Table 5 Effect of AA on antioxidant enzymes viz. CAT, SOD, GST, GPx, G6PD and GR of T2D rats

From: Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response

Parameters

Gr I

Gr II

Gr III

Gr IV

Gr V

Kidney

     

CAT (U mg−1 of protein)

226.34 ± 16.33

153.74 ± 9.11#

207.28 ± 12.03*

212.65 ± 13.77*

216.33 ± 17.88*

SOD (U mg−1 of protein)

140.32 ± 7.05

98.51 ± 6.16#

123.82 ± 6.07*

129.15 ± 6.92**

128.56 ± 6.94*

GST (μmol h−1 mg−1 of protein)

0.71 ± 0.07

0.46 ± 0.04$

0.59 ± 0.05

0.68 ± 0.06*

0.67 ± 0.04*

GPx (nmol min−1 mg−1 of protein)

68.20 ± 5.91

40.43 ± 5.57$

54.20 ± 6.12

59.93 ± 8.63

61.82 ± 6.64

GR (nmol min−1 mg−1 of protein)

69.81 ± 4.90

41.82 ± 3.31#

59.48 ± 5.63

61.63 ± 5.74*

63.85 ± 6.30*

G6PD (nmol min−1 mg−1 of protein)

133.64 ± 7.07

97.44 ± 5.19#

117.65 ± 7.69

125.38 ± 8.57*

126.41 ± 6.45*

Heart

     

CAT (U mg−1 of protein)

287.50 ± 11.61

192.26 ± 10.52#

230.63 ± 16.50

255.41 ± 15.18*

254.98 ± 20.62*

SOD (U mg−1 of protein)

133.66 ± 7.54

95.14 ± 4.66#

115.45 ± 7.67

121.96 ± 7.18*

123.60 ± 7.82*

GST (μmol h−1 mg−1 of protein)

1.63 ± 0.13

1.07 ± 0.12#

1.47 ± 0.10

1.53 ± 0.13*

1.55 ± 0.11*

GPx (nmol min−1 mg−1 of protein)

81.49 ± 8.08

96.74 ± 7.01#

133.45 ± 10.13*

138.62 ± 10.69*

139.69 ± 8.35**

GR (nmol min−1 mg−1 of protein)

26.87 ± 2.45

50.20 ± 4.29#

67.20 ± 4.70

73.28 ± 6.67*

75.08 ± 4.69*

G6PD (nmol min−1 mg−1 of protein)

101.70 ± 7.04

71.23 ± 4.22#

88.48 ± 6.29

94.55 ± 4.03*

92.90 ± 4.43*

  1. Data were expressed as mean ± SE (n = 6). $ p < 0.05 compared with normal control group. # p < 0.01 compared with normal control group. *p < 0.05 compared with diabetic control group. **p < 0.01 compared with diabetic control group. Gr I: Normal; Gr II: T2D control, Gr III: T2D + AA (100 mg/kg, p.o.); Gr IV: T2D + AA (200 mg/kg, p.o.); Gr V: T2D + glibenclamide (1 mg/kg, p.o.).