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Table 5 Effect of AA on antioxidant enzymes viz. CAT, SOD, GST, GPx, G6PD and GR of T2D rats

From: Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response

Parameters Gr I Gr II Gr III Gr IV Gr V
Kidney      
CAT (U mg−1 of protein) 226.34 ± 16.33 153.74 ± 9.11# 207.28 ± 12.03* 212.65 ± 13.77* 216.33 ± 17.88*
SOD (U mg−1 of protein) 140.32 ± 7.05 98.51 ± 6.16# 123.82 ± 6.07* 129.15 ± 6.92** 128.56 ± 6.94*
GST (μmol h−1 mg−1 of protein) 0.71 ± 0.07 0.46 ± 0.04$ 0.59 ± 0.05 0.68 ± 0.06* 0.67 ± 0.04*
GPx (nmol min−1 mg−1 of protein) 68.20 ± 5.91 40.43 ± 5.57$ 54.20 ± 6.12 59.93 ± 8.63 61.82 ± 6.64
GR (nmol min−1 mg−1 of protein) 69.81 ± 4.90 41.82 ± 3.31# 59.48 ± 5.63 61.63 ± 5.74* 63.85 ± 6.30*
G6PD (nmol min−1 mg−1 of protein) 133.64 ± 7.07 97.44 ± 5.19# 117.65 ± 7.69 125.38 ± 8.57* 126.41 ± 6.45*
Heart      
CAT (U mg−1 of protein) 287.50 ± 11.61 192.26 ± 10.52# 230.63 ± 16.50 255.41 ± 15.18* 254.98 ± 20.62*
SOD (U mg−1 of protein) 133.66 ± 7.54 95.14 ± 4.66# 115.45 ± 7.67 121.96 ± 7.18* 123.60 ± 7.82*
GST (μmol h−1 mg−1 of protein) 1.63 ± 0.13 1.07 ± 0.12# 1.47 ± 0.10 1.53 ± 0.13* 1.55 ± 0.11*
GPx (nmol min−1 mg−1 of protein) 81.49 ± 8.08 96.74 ± 7.01# 133.45 ± 10.13* 138.62 ± 10.69* 139.69 ± 8.35**
GR (nmol min−1 mg−1 of protein) 26.87 ± 2.45 50.20 ± 4.29# 67.20 ± 4.70 73.28 ± 6.67* 75.08 ± 4.69*
G6PD (nmol min−1 mg−1 of protein) 101.70 ± 7.04 71.23 ± 4.22# 88.48 ± 6.29 94.55 ± 4.03* 92.90 ± 4.43*
  1. Data were expressed as mean ± SE (n = 6). $ p < 0.05 compared with normal control group. # p < 0.01 compared with normal control group. *p < 0.05 compared with diabetic control group. **p < 0.01 compared with diabetic control group. Gr I: Normal; Gr II: T2D control, Gr III: T2D + AA (100 mg/kg, p.o.); Gr IV: T2D + AA (200 mg/kg, p.o.); Gr V: T2D + glibenclamide (1 mg/kg, p.o.).