Skip to main content

Table 4 Effect of AA on ROS production, lipid peroxidation (TBARS), protein carbonyation, ubiquinones (coenzyme Q9 and Q10) and GSH level of T2D rats

From: Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response

Parameters Gr I Gr II Gr III Gr IV Gr V
Kidney      
ROS production (nmol DCF min−1 mg−1 of protein) 36.84 ± 3.14 75.47 ± 4.56# 53.51 ± 6.39** 46.89 ± 4.39** 57.85 ± 3.01*
Lipid peroxidation (TBARS level in μg g−1 of tissue) 4.56 ± 0.32 7.20 ± 0.45# 5.56 ± 0.57* 5.47 ± 0.33* 5.71 ± 0.49*
Protein cabonylation (nmol mg−1 of protein) 8.71 ± 0.72 17.71 ± 1.51# 13.20 ± 1.32* 11.17 ± 1.06** 11.36 ± 1.27**
Total coenzyme Q9 (nmol g−1 of wet tissue) 148.80 ± 4.31 116.50 ± 5.46# 127.33 ± 4.45 137.71 ± 5.57* 143.20 ± 4.61**
Total coenzyme Q10 (nmol g−1 of wet tissue) 25.38 ± 1.66 16.88 ± 1.78# 21.75 ± 1.87 23.60 ± 1.82* 21.32 ± 1.73
GSH (mg g−1 tissue) 25.56 ± 1.52 15.12 ± 0.98# 20.08 ± 1.43 22.32 ± 1.87** 23.60 ± 1.61**
Heart      
ROS production (nmol DCF min−1 mg−1 of protein) 25.89 ± 1.46 58.14 ± 3.84# 40.77 ± 3.72** 37.83 ± 3.01** 45.94 ± 2.82**
Lipid peroxidation (TBARS level in μg g−1 of tissue) 3.55 ± 0.24 6.30 ± 0.37# 5.09 ± 0.33* 4.61 ± 0.34** 4.94 ± 0.20*
Protein cabonylation (nmol mg−1 of protein) 2.48 ± 0.26 5.09 ± 0.42# 3.73 ± 0.27* 3.06 ± 0.22** 3.02 ± 0.31**
Total coenzyme Q9 (nmol g−1 of wet tissue) 59.12 ± 2.88 43.01 ± 3.15$ 51.03 ± 3.94 54.44 ± 3.80 55.46 ± 4.30*
Total coenzyme Q10 (nmol g−1 of wet tissue) 26.87 ± 2.45 15.84 ± 1.93$ 22.42 ± 3.18 25.80 ± 2.77* 25.05 ± 2.42
GSH (mg g−1 tissue) 22.13 ± 1.54 12.28 ± 1.78# 17.40 ± 2.39 19.60 ± 1.24* 19.31 ± 1.92*
  1. Data were expressed as mean ± SE (n = 6). $ p < 0.05 compared with normal control group. # p < 0.01 compared with normal control group. *p < 0.05 compared with diabetic control group. **p < 0.01 compared with diabetic control group. Gr I: Normal; Gr I: Normal; Gr II: T2D control, Gr III: T2D + AA (100 mg/kg, p.o.); Gr IV: T2D + AA (200 mg/kg, p.o.); Gr V: T2D + glibenclamide (1 mg/kg, p.o.).