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Table 4 Effect of AA on ROS production, lipid peroxidation (TBARS), protein carbonyation, ubiquinones (coenzyme Q9 and Q10) and GSH level of T2D rats

From: Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response

Parameters

Gr I

Gr II

Gr III

Gr IV

Gr V

Kidney

     

ROS production (nmol DCF min−1 mg−1 of protein)

36.84 ± 3.14

75.47 ± 4.56#

53.51 ± 6.39**

46.89 ± 4.39**

57.85 ± 3.01*

Lipid peroxidation (TBARS level in μg g−1 of tissue)

4.56 ± 0.32

7.20 ± 0.45#

5.56 ± 0.57*

5.47 ± 0.33*

5.71 ± 0.49*

Protein cabonylation (nmol mg−1 of protein)

8.71 ± 0.72

17.71 ± 1.51#

13.20 ± 1.32*

11.17 ± 1.06**

11.36 ± 1.27**

Total coenzyme Q9 (nmol g−1 of wet tissue)

148.80 ± 4.31

116.50 ± 5.46#

127.33 ± 4.45

137.71 ± 5.57*

143.20 ± 4.61**

Total coenzyme Q10 (nmol g−1 of wet tissue)

25.38 ± 1.66

16.88 ± 1.78#

21.75 ± 1.87

23.60 ± 1.82*

21.32 ± 1.73

GSH (mg g−1 tissue)

25.56 ± 1.52

15.12 ± 0.98#

20.08 ± 1.43

22.32 ± 1.87**

23.60 ± 1.61**

Heart

     

ROS production (nmol DCF min−1 mg−1 of protein)

25.89 ± 1.46

58.14 ± 3.84#

40.77 ± 3.72**

37.83 ± 3.01**

45.94 ± 2.82**

Lipid peroxidation (TBARS level in μg g−1 of tissue)

3.55 ± 0.24

6.30 ± 0.37#

5.09 ± 0.33*

4.61 ± 0.34**

4.94 ± 0.20*

Protein cabonylation (nmol mg−1 of protein)

2.48 ± 0.26

5.09 ± 0.42#

3.73 ± 0.27*

3.06 ± 0.22**

3.02 ± 0.31**

Total coenzyme Q9 (nmol g−1 of wet tissue)

59.12 ± 2.88

43.01 ± 3.15$

51.03 ± 3.94

54.44 ± 3.80

55.46 ± 4.30*

Total coenzyme Q10 (nmol g−1 of wet tissue)

26.87 ± 2.45

15.84 ± 1.93$

22.42 ± 3.18

25.80 ± 2.77*

25.05 ± 2.42

GSH (mg g−1 tissue)

22.13 ± 1.54

12.28 ± 1.78#

17.40 ± 2.39

19.60 ± 1.24*

19.31 ± 1.92*

  1. Data were expressed as mean ± SE (n = 6). $ p < 0.05 compared with normal control group. # p < 0.01 compared with normal control group. *p < 0.05 compared with diabetic control group. **p < 0.01 compared with diabetic control group. Gr I: Normal; Gr I: Normal; Gr II: T2D control, Gr III: T2D + AA (100 mg/kg, p.o.); Gr IV: T2D + AA (200 mg/kg, p.o.); Gr V: T2D + glibenclamide (1 mg/kg, p.o.).