Figure 4

Therapeutic efficacy of HBV ⁺ DRibbles vaccine. The schematic diagram outlines the experiment protocol (A). Lymphocytes from the acute HBV-infected mice received HBV⁺ DRibbles or HBsAg or PBS were isolated and re-stimulated with HBV antigens or peptides and the number of IFN-γ producing cells in 2 × 10⁵ lymphocytes was detected as described (n = 3) (B-D). Serum HBeAg (E), HBsAg (F), HBV DNA copy number (G) and the percentage of HBcAg⁺ hepatocytes (H) of immunized mice or control mice were measured as mentioned above (n = 6). These experiments were repeated three times.